Which of the following are the three main safeguards under the Security Rule?

The three main safeguards under the Security Rule of HIPAA are administrative, physical, and technical safeguards.

Administrative safeguards involve policies and procedures designed to manage the selection, development, implementation, and maintenance of security measures to protect electronic protected health information (ePHI). This includes workforce training, security management processes, and contingency planning.

Physical safeguards are the physical measures, policies, and procedures that protect a covered entity's electronic information systems and related buildings and equipment from unauthorized access, tampering, or theft. This includes controlled access to facilities and workstation security.

Technical safeguards are the technology and the policies and procedures for its use that protect ePHI and control access to it. This includes access controls, encryption, and auditing measures to ensure that only authorized users can access ePHI.

Together, these three categories form a comprehensive approach to protecting the confidentiality, integrity, and availability of electronic health information. They are explicitly defined and required under the HIPAA Security Rule, making this answer the most accurate choice.